Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are deleted selectively in β cells, provide a unique mode...

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Bibliographic Details
Main Authors: Melissa T Adams, JaeAnn M Dwulet, Jennifer K Briggs, Christopher A Reissaus, Erli Jin, Joseph M Szulczewski, Melissa R Lyman, Sophia M Sdao, Vira Kravets, Sutichot D Nimkulrat, Suzanne M Ponik, Matthew J Merrins, Raghavendra G Mirmira, Amelia K Linnemann, Richard KP Benninger, Barak Blum
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
islets of Langerhans
beta cells
robo receptors
islet architecture
synchronous insulin secretion
intravital microscopy
Online Access:https://elifesciences.org/articles/61308

Internet

https://elifesciences.org/articles/61308

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