Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and five granzymes (GrA, GrB, GrH, GrK, GrM), whic...

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Bibliographic Details
Main Authors: Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008426

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https://doi.org/10.1371/journal.ppat.1008426

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