Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO

Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO

Abstract Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with long turnaround times. Thus, preempting batch failu...

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Bibliographic Details
Main Authors: Geoffri Ricci, Kevin Minsker, Austin Kapish, James Osborn, Sha Ha, Joseph Davide, Joseph P. Califano, Darrell Sehlin, Richard R. Rustandi, Lawrence W. Dick, Josef Vlasak, Timothy D. Culp, Andreas Baudy, Edward Bell, Malini Mukherjee
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86688-z

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https://doi.org/10.1038/s41598-021-86688-z

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