Epigenetic-based therapies for Friedreich ataxia

Epigenetic-based therapies for Friedreich ataxia

Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron of the FXN gene, leading to inhibition of FXN transcription and thus reduced frataxin protein expression. Recent studies have sho...

Full description

Bibliographic Details
Main Authors: Chiranjeevi eSandi, Madhavi eSandi, Sara eAnjomani-Virmouni, Sahar eAl-Mahdawi, Mark Adrian Pook
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Genetics
Subjects:
Friedreich Ataxia
DNA demethylation
frataxin
FRDA
FXN
GAA repeat
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00165/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00165/full

Similar Items