Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

Abstract Background Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neurop...

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Bibliographic Details
Main Authors: Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang, Wen-Ning Wu
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Epilepsy
Inflammation
Sinomenine
Pentylenetetrazole
NLRP1 inflammasome
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-018-1199-0

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http://link.springer.com/article/10.1186/s12974-018-1199-0

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