The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms

The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms

Approximately 20% of unselected cases and 30% cytogenetically diploid cases of acute myeloid leukemia (AML) and 80% of grade II-III gliomas and secondary glioblastomas carry mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. IDH1/2 mutations prevent oxidative decarboxylation of isocitrat...

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Bibliographic Details
Main Authors: Dinesh eRakheja, L Jeffrey Medeiros, Scott eBevan, Weina eChen
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Oncology
Subjects:
Glioma
Acute Myeloid Leukemia
IDH mutation
NPM1 mutation
D-2-Hydroxyglutarate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00169/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00169/full

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