Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23

Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23

Craniofacial development is a program exquisitely orchestrated by tissue contributions and regulation of genes expression. The basic helix–loop–helix (bHLH) transcription factor Twist1 expressed in the skeletal mesenchyme is a key regulator of craniofacial development playing an important role durin...

Full description

Bibliographic Details
Main Authors: Natalina Quarto, Siny Shailendra, Nathaniel P. Meyer, Siddharth Menon, Andrea Renda, Michael T. Longaker
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
Twist1
haploinsuffiency
Fgf23
downregulation
enhancement
osteoskeletogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01426/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01426/full

Similar Items