Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on and quickly turns off downstream signaling as it translocates from the ER to vesicles. How STING signaling is attenuated during trafficking remains poorly understood. Here, we show that trafficking-mediated STING d...

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Bibliographic Details
Main Authors: Vijay K. Gonugunta, Tomomi Sakai, Vladislav Pokatayev, Kun Yang, Jianjun Wu, Nicole Dobbs, Nan Yan
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
STING degradation
lysosomes
anti-tumor response
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317138

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717317138

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