Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA syn...

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Bibliographic Details
Main Authors: Nicholas Chim, Lynnette N Jackson, Anh M Trinh, John C Chaput
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
DNA polymerase
crystallography
mechanism
Online Access:https://elifesciences.org/articles/40444

Internet

https://elifesciences.org/articles/40444

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