Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling.

Bistability has important implications in signaling pathways, since it indicates a potential cell decision between alternative outcomes. We present two approaches developed in the framework of the Chemical Reaction Network Theory for easy and efficient search of multiple steady state behavior in sig...

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Bibliographic Details
Main Authors: Irene Otero-Muras, Pencho Yordanov, Joerg Stelling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1005454