17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway

17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway

Aims: To explore the molecular mechanism by which 17β-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet β cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway.Methods: SPF-grade SD male rats were used to establish an in vivo ty...

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Bibliographic Details
Main Authors: Che Bian, Bowen Bai, Qian Gao, Siyi Li, Yuyan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Endocrinology
Subjects:
17β-estradiol
islet β cells
type 2 diabetes mellitus
glucose transporter 2
insulin secretion
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00531/full

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