Modeling the Human Bone–Tumor Niche: Reducing and Replacing the Need for Animal Data

ABSTRACT Bone is the most common site for cancer metastasis. Understanding the interactions within the complex, heterogeneous bone–tumor microenvironment is essential for the development of new therapeutics. Various animal models of tumor‐induced bone disease are routinely used to provide valuable i...

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Bibliographic Details
Main Authors: Srinivasa R Rao, Claire M Edwards, James R Edwards
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10356