Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

The burden of somatic mutations and neoantigens has been associated with improved survival in cancer treated with immunotherapies, especially non-small cell lung cancer (NSCLC). However, there is uncertainty about their effect on outcome in early-stage untreated cases. We posited that the burden of...

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Bibliographic Details
Main Authors: Dennis Wang, Nhu-An Pham, Timothy M. Freeman, Vibha Raghavan, Roya Navab, Jonathan Chang, Chang-Qi Zhu, Dalam Ly, Jiefei Tong, Bradly G. Wouters, Melania Pintilie, Michael F. Moran, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
cancer genomics
prognosis
mutation burden
copy number
patient stratification
cancer immunology
oncogenic pathways
patient-derived xenograft
Online Access:https://www.mdpi.com/2072-6694/11/7/1009

Internet

https://www.mdpi.com/2072-6694/11/7/1009

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