Toxin ζ Reversible Induces Dormancy and Reduces the UDP-N-Acetylglucosamine Pool as One of the Protective Responses to Cope with Stress

Toxin ζ Reversible Induces Dormancy and Reduces the UDP-N-Acetylglucosamine Pool as One of the Protective Responses to Cope with Stress

Toxins of the ζ/PezT family, found in the genome of major human pathogens, phosphorylate the peptidoglycan precursor uridine diphosphate-N-acetylglucosamine (UNAG) leading to unreactive UNAG-3P. Transient over-expression of a PezT variant impairs cell wall biosynthesis and triggers autolysis in Esch...

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Bibliographic Details
Main Authors: Mariangela Tabone, Silvia Ayora, Juan C. Alonso
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Toxins
Subjects:
toxin-antitoxin system
fosfomycin
vancomycin
ampicillin
bacterial persistence
Online Access:http://www.mdpi.com/2072-6651/6/9/2787

Internet

http://www.mdpi.com/2072-6651/6/9/2787

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