Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.

Bibliographic Details
Main Authors: Christine-Maria Horejs, Jean-Philippe St-Pierre, Juha R. M. Ojala, Joseph A. M. Steele, Patricia Barros da Silva, Angela Rynne-Vidal, Stephanie A. Maynard, Catherine S. Hansel, Clara Rodríguez-Fernández, Manuel M. Mazo, Amanda Y. F. You, Alex J. Wang, Thomas von Erlach, Karl Tryggvason, Manuel López-Cabrera, Molly M. Stevens
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15509

Internet

https://doi.org/10.1038/ncomms15509

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