Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons

Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons

Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity...

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Bibliographic Details
Main Author: Anđus P.R.
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2007-01-01
Series:Archives of Biological Sciences
Subjects:
Amyotrophic lateral sclerosis
IgG
glycinergic synapses
postsynaptic currents
brain-stem slices
patch-clamp
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf

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http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf

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