Distinct BTK inhibitors differentially induce apoptosis but similarly suppress chemotaxis and lipid accumulation in mantle cell lymphoma

Distinct BTK inhibitors differentially induce apoptosis but similarly suppress chemotaxis and lipid accumulation in mantle cell lymphoma

Abstract Background The more selective second-generation BTK inhibitors (BTKi) Acalabrutinib and Zanubrutinib and the first-generation BTKi Ibrutinib are highlighted by their clinical effectiveness in mantle cell lymphoma (MCL), however, similarities and differences of their biological and molecular...

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Bibliographic Details
Main Authors: Zhuojun Liu, Jia Liu, Tianming Zhang, Lin Li, Shuo Zhang, Hao Jia, Yuanshi Xia, Mingxia Shi, Jing Zhang, Shuhua Yue, Xiaofang Chen, Jian Yu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Cancer
Subjects:
Mantle cell lymphoma
Ibrutinib
Acalabrutinib
Zanubrutinib
Apoptosis
Chemotaxis
Online Access:https://doi.org/10.1186/s12885-021-08475-3

Internet

https://doi.org/10.1186/s12885-021-08475-3

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