Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics. Several inducers of acute pancreatitis trigger sustained Ca<sup>2+</sup> increases in the cytosol...

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Bibliographic Details
Main Authors: Michael Chvanov, Svetlana Voronina, Xiaoying Zhang, Svetlana Telnova, Robert Chard, Yulin Ouyang, Jane Armstrong, Helen Tanton, Muhammad Awais, Diane Latawiec, Robert Sutton, David N. Criddle, Alexei V. Tepikin
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
acute pancreatitis
Ca<sup>2+</sup> signaling
mitochondrial calcium uniporter
pancreatic acinar cells
Online Access:https://www.mdpi.com/2073-4409/9/6/1407

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https://www.mdpi.com/2073-4409/9/6/1407

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