Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors

Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors

Abstract We have examined the regulation of mutually exclusive Cav2.2 exon 37a and b variants by the mouse μ-opioid receptor (mMOR) C-terminal splice variants 1, 1C and 1O in tsA-201 cells. Electrophysiological analyses revealed that both channel isoforms exhibit DAMGO-induced voltage-dependent (Gβγ...

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Bibliographic Details
Main Authors: Maria A. Gandini, Ivana A. Souza, Dvij Raval, Jin Xu, Ying-Xian Pan, Gerald W. Zamponi
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Brain
Subjects:
N-type
Calcium channel
Cav2.2
Opioid receptor
Splicing
G proteins
Online Access:http://link.springer.com/article/10.1186/s13041-019-0524-6

Internet

http://link.springer.com/article/10.1186/s13041-019-0524-6

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