DNA methylation supports intrinsic epigenetic memory in mammalian cells.
We have investigated the role of DNA methylation in the initiation and maintenance of silenced chromatin in somatic mammalian cells. We found that a mutated transgene, in which all the CpG dinucleotides have been eliminated, underwent transcriptional silencing to the same extent as the unmodified tr...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-04-01
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| Series: | PLoS Genetics |
| Online Access: | http://dx.doi.org/10.1371/journal.pgen.0020065 |