Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

Summary: Huntington’s disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of the striatal projection neurons (SPNs) of the striatum...

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Bibliographic Details
Main Authors: Caley J. Burrus, Spencer U. McKinstry, Namsoo Kim, M. Ilcim Ozlu, Aditya V. Santoki, Francia Y. Fang, Annie Ma, Yonca B. Karadeniz, Atesh K. Worthington, Ioannis Dragatsis, Scott Zeitlin, Henry H. Yin, Cagla Eroglu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719317267

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http://www.sciencedirect.com/science/article/pii/S2211124719317267

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