Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular la...

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Bibliographic Details
Main Authors: Leah M Prentice, Ruth R Miller, Jeff Knaggs, Alborz Mazloomian, Rosalia Aguirre Hernandez, Patrick Franchini, Kourosh Parsa, Basile Tessier-Cloutier, Anna Lapuk, David Huntsman, David F Schaeffer, Brandon S Sheffield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5919577?pdf=render

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http://europepmc.org/articles/PMC5919577?pdf=render

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