Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof-of-concept study

Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof-of-concept study

Therapeutically intervening the function of RNA in vivo remains a big challenge. We here developed an exosome-based strategy to deliver engineered RNA-binding protein for the purpose of recruiting specific RNA to the lysosomes for degradation. As a proof-of-principle study, RNA-binding protein HuR w...

Full description

Bibliographic Details
Main Authors: Zhelong Li, Xueying Zhou, Xiaotong Gao, Danna Bai, Yan Dong, Wenqi Sun, Lianbi Zhao, Mengying Wei, Xuekang Yang, Guodong Yang, Lijun Yuan
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Extracellular Vesicles
Subjects:
hur
lamp2b
exosomes
lysosome
protein delivery
Online Access:http://dx.doi.org/10.1080/20013078.2020.1816710

Internet

http://dx.doi.org/10.1080/20013078.2020.1816710

Similar Items