Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Nuclear factor 90 (NF90) is a novel virus sensor that serves to initiate antiviral innate immunity by triggering stress granule (SG) formation. However, the regulation of the NF90-SG pathway remains largely unclear. We found that Tim-3, an immune checkpoint inhibitor, promotes the ubiquitination and...

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Bibliographic Details
Main Authors: Shuaijie Dou, Guoxian Li, Ge Li, Chunmei Hou, Yang Zheng, Lili Tang, Yang Gao, Rongliang Mo, Yuxiang Li, Renxi Wang, Beifen Shen, Jun Zhang, Gencheng Han
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
Tim-3
virus sensor
NF90
ubiquitination
antiviral innate immunity
Online Access:https://elifesciences.org/articles/66501

Internet

https://elifesciences.org/articles/66501

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