Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age

Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age

The molecular underpinnings associated with cognitive reserve remain poorly understood. Because animal models fail to fully recapitulate the complexity of human brain aging, postmortem studies from well-designed cohorts are crucial to unmask mechanisms conferring cognitive resistance against cumulat...

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Bibliographic Details
Main Authors: Alfredo Ramos-Miguel, Andrea A. Jones, Ken Sawada, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Neurobiology of Disease
Subjects:
SNARE complex
Protein-protein interactions
Native PAGE
Postmortem brain
Synaptic pathology
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830038X

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http://www.sciencedirect.com/science/article/pii/S096999611830038X

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