Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning

Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning

Drug discovery is a very expensive and time-consuming endeavor. Fortunately, recent omics technologies and Systems Biology approaches introduced interesting new tools to achieve this task, facilitating the repurposing of already known drugs to new therapeutic assignments using gene expression data a...

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Bibliographic Details
Main Authors: Marco A. De Bastiani, Bianca Pfaffenseller, Fabio Klamt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
connectivity map
computational drug repositioning
master regulators
transcription factors
reverse engineering
systems pharmacology
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00697/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00697/full

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