Irbesartan-mediated AT receptor blockade attenuates hyposmotic-induced enhancement of current and prevents shortening of action potential duration in atrial myocytes
Introduction: Stretch of the atrial membrane upregulates the slow component of delayed rectifier K + current ( I Ks ). Blockade of angiotensin II subtype 1 receptors (AT 1 R) attenuates this increase in I Ks . The present study aimed to examine the effects of irbesartan, a selective AT 1 R blocker (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi - SAGE Publishing
2014-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312474855 |