Exacerbated Airway Toxicity of Environmental Oxidant Ozone in Mice Deficient in Nrf2

Ozone (O3) is a strong oxidant in air pollution that has harmful effects on airways and exacerbates respiratory disorders. The transcription factor Nrf2 protects airways from oxidative stress through antioxidant response element-bearing defense gene induction. The present study was designed to deter...

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Bibliographic Details
Main Authors: Hye-Youn Cho, Wesley Gladwell, Masayuki Yamamoto, Steven R. Kleeberger
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2013/254069