Drug repositioning for a rare genetic disorder progressive osseous heteroplasia (POH)

Drug repositioning for a rare genetic disorder progressive osseous heteroplasia (POH)

Progressive osseous heteroplasia (POH) is an ultrarare genetic disease of progressive ectopic ossification caused by heterozygous inactivating mutations of GNAS, the gene encoding the alpha subunit of the G-stimulatory protein of adenylyl cyclase (Gsα). Extensive ossification of the deep...

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Bibliographic Details
Main Authors: Gvozdenović-Jeremić Jelena, Mojović Ljiljana
Format: Article
Language:English
Published: Serbian Genetics Society 2019-01-01
Series:Genetika
Subjects:
drug repurposing
ectopic ossification
Hedgehog pathway inhibitors
mesenchymal progenitor cells
Progressive Osseous Heteroplasia
Online Access:http://www.doiserbia.nb.rs/img/doi/0534-0012/2019/0534-00121901347G.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0534-0012/2019/0534-00121901347G.pdf

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