Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope

Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope

The Gibbon Ape Leukemia Virus envelope protein (GALV-Env) mediates efficient transduction of human cells, particularly primary B and T lymphocytes, and is therefore of great interest in gene therapy. Using internal domains from murine leukemia viruses (MLV), chimeric GALV-Env proteins such as GALV-C...

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Bibliographic Details
Main Authors: Manuela Mirow, Lea Isabell Schwarze, Boris Fehse, Kristoffer Riecken
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
retroviral vectors
adoptive immunotherapy
chimeric antigen receptor (CAR)
T-cell receptor (TCR)
gene therapy
pseudotyping
Online Access:https://www.mdpi.com/1999-4915/13/8/1471

Internet

https://www.mdpi.com/1999-4915/13/8/1471

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