MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings

MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings

Glioma is the most malignant brain tumors in the world, the function and molecular mechanism of microRNA-199a (miR-199a) in glioma is not fully understood. Our research aims to investigate miR-199a/K-RAS axis in regulation of glioma tumor growth and chemoresistance. The function of miR-199a in gliom...

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Bibliographic Details
Main Authors: Wei Li, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Xin Ge, Wei-Tao Liu, Ling Chen, Zhong Zheng, Zhu-Mei Shi, Ling-Zhi Liu, Marie C. Lin, Jie-Yu Chen, Bing-Hua Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
miR-199a
glioma
K-RAS
chemoresistance
tumorigenesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01071/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01071/full

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