Abortive T follicular helper development is associated with a defective humoral response in Leishmania infantum-infected macaques.

Abortive T follicular helper development is associated with a defective humoral response in Leishmania infantum-infected macaques.

Leishmania infantum causes a chronic infectious disease named visceral leishmaniasis (VL). We employed a non-human primate model to monitor immune parameters over time and gain new insights into the disease. Rhesus macaques were infected with L. infantum and the T helper and B cell immunological pro...

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Bibliographic Details
Main Authors: Vasco Rodrigues, Mireille Laforge, Laure Campillo-Gimenez, Calaiselvy Soundaramourty, Ana Correia-de-Oliveira, Ricardo Jorge Dinis-Oliveira, Ali Ouaissi, Anabela Cordeiro-da-Silva, Ricardo Silvestre, Jérôme Estaquier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4005728?pdf=render

Internet

http://europepmc.org/articles/PMC4005728?pdf=render

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