Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Chronic kidney disease (CKD) causes progressive skeletal myopathy involving atrophy, weakness, and fatigue. Mitochondria have been thought to contribute to skeletal myopathy; however, the molecular mechanisms underlying muscle metabolism changes in CKD are unknown. We employed a comprehensive mitoch...

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Bibliographic Details
Main Authors: Trace Thome, Ravi A. Kumar, Sarah K. Burke, Ram B. Khattri, Zachary R. Salyers, Rachel C. Kelley, Madeline D. Coleman, Demetra D. Christou, Russell T. Hepple, Salvatore T. Scali, Leonardo F. Ferreira, Terence E. Ryan
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-01-01
Series:JCI Insight
Subjects:
Muscle biology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.139826

Internet

https://doi.org/10.1172/jci.insight.139826

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