Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease

Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease

Background: Ataxia Telangiectasia Mutated (ATM) serine/threonine protein kinase is a known tumor suppressor, involved in DNA damage repair. It has prognostic and predictive therapeutic implications and is associated with aggressive prostate cancer (PCa). Objective: To investigate the prognostic valu...

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Bibliographic Details
Main Authors: Simon R. Walker, Ramy Abdelsalam, Sunita Ghosh, Julie Livingstone, Nallasivam Palanisamy, Paul C. Boutros, Steven M. Yip, Susan P. Lees-Miller, Tarek A. Bismar
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:European Urology Open Science
Subjects:
ATM
PTEN
ERG
Protein expression
Immunohistochemistry
Gleason score
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168321000951

Internet

http://www.sciencedirect.com/science/article/pii/S2666168321000951

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