Role of influenza A virus NP acetylation on viral growth and replication

Role of influenza A virus NP acetylation on viral growth and replication

Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and viri...

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Main Authors: Sebastian Giese, Kevin Ciminski, Hardin Bolte, Étori Aguiar Moreira, Seema Lakdawala, Zehan Hu, Quinnlan David, Larissa Kolesnikova, Veronika Götz, Yongxu Zhao, Jörn Dengjel, Y. Eugene Chin, Ke Xu, Martin Schwemmle
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01112-3
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spelling doaj-6ed0845914b74bd29b55b944319e93732021-05-11T07:43:34ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-01112-3Role of influenza A virus NP acetylation on viral growth and replicationSebastian Giese0Kevin Ciminski1Hardin Bolte2Étori Aguiar Moreira3Seema Lakdawala4Zehan Hu5Quinnlan David6Larissa Kolesnikova7Veronika Götz8Yongxu Zhao9Jörn Dengjel10Y. Eugene Chin11Ke Xu12Martin Schwemmle13Institute of Virology, Medical Center University of FreiburgInstitute of Virology, Medical Center University of FreiburgInstitute of Virology, Medical Center University of FreiburgInstitute of Virology, Medical Center University of FreiburgDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Dermatology, Medical Center, University of FreiburgInstitute of Virology, Medical Center University of FreiburgInstitute of Virology, Philipps-Universität MarburgInstitute of Virology, Medical Center University of FreiburgInstitute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDepartment of Dermatology, Medical Center, University of FreiburgInstitute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Virology, Medical Center University of FreiburgPost-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.https://doi.org/10.1038/s41467-017-01112-3
collection DOAJ
language English
format Article
sources DOAJ
author Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
spellingShingle Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
Role of influenza A virus NP acetylation on viral growth and replication
Nature Communications
author_facet Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
author_sort Sebastian Giese
title Role of influenza A virus NP acetylation on viral growth and replication
title_short Role of influenza A virus NP acetylation on viral growth and replication
title_full Role of influenza A virus NP acetylation on viral growth and replication
title_fullStr Role of influenza A virus NP acetylation on viral growth and replication
title_full_unstemmed Role of influenza A virus NP acetylation on viral growth and replication
title_sort role of influenza a virus np acetylation on viral growth and replication
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.
url https://doi.org/10.1038/s41467-017-01112-3
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