Case Report: Preimplantation Genetic Testing and Pregnancy Outcomes in Women With Alport Syndrome

Case Report: Preimplantation Genetic Testing and Pregnancy Outcomes in Women With Alport Syndrome

BackgroundAlport syndrome, a monogenic kidney disease, is characterized by progressive hemorrhagic nephritis, sensorineural hearing loss, and ocular abnormalities. Mutations in COL4A5 at Xq22 accounts for 80–85% of X-linked Alport syndrome patients. Three couples were referred to our reproductive ge...

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Bibliographic Details
Main Authors: Wei-Hui Shi, Mu-Jin Ye, Song-Chang Chen, Jun-Yu Zhang, Yi-Yao Chen, Zhi-Yang Zhou, Ning-Xin Qin, Xuan-You Zhou, Nai-Xin Xu, Zi-Ru Jiang, Jing Lin, He-Feng Huang, Chen-Ming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Genetics
Subjects:
X-linked Alport syndrome
preimplantation genetic testing
haplotype analysis
prenatal diagnosis
pregnancy
proteinuria
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.633003/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.633003/full

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