Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function

Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function

Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction is not well understood. We employed mass spectrometry (MS)-based quantitative...

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Bibliographic Details
Main Authors: Fabian Hosp, Sara Gutiérrez-Ángel, Martin H. Schaefer, Jürgen Cox, Felix Meissner, Mark S. Hipp, F.-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
Huntington’s disease
inclusion bodies
cerebrospinal fluid
neurodegeneration
quantitative proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315772

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