Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.

Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.

BACKGROUND:Achaete scute-like 2 (Ascl2), a basic helix-loop-helix (bHLH) transcription factor, controls the fate of intestinal stem cells. However, the role of Ascl2 in colon cancer progenitor cells remains unknown. The cell line HT-29 (47.5-95% of CD133(+) population) and LS174T (0.45% of CD133(+)...

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Main Authors: Rong Zhu, Yongtao Yang, Yin Tian, Jianying Bai, Xin Zhang, Xiaohuan Li, Zhihong Peng, Yonghong He, Lei Chen, Qiong Pan, Dianchun Fang, Wensheng Chen, Chen Qian, Xiuwu Bian, Rongquan Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285660?pdf=render

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http://europepmc.org/articles/PMC3285660?pdf=render

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