Perinatal Na+ overload programs raised renal proximal Na+ transport and enalapril-sensitive alterations of Ang II signaling pathways during adulthood.

BACKGROUND: High Na(+) intake is a reality in nowadays and is frequently accompanied by renal and cardiovascular alterations. In this study, renal mechanisms underlying perinatal Na(+) overload-programmed alterations in Na(+) transporters and the renin/angiotensin system (RAS) were investigated, tog...

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Main Authors: Edjair V Cabral, Leucio D Vieira-Filho, Paulo A Silva, Williams S Nascimento, Regina S Aires, Fabiana S T Oliveira, Ricardo Luzardo, Adalberto Vieyra, Ana D O Paixão
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3425503?pdf=render