The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes

The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes

Aim: Channelrhodopsins (ChRs) are a large family of light-gated ion channels with distinct properties, which is of great importance in the selection of a ChR variant for a given application. However, data to guide such selection for cardiac optogenetic applications are lacking. Therefore, we investi...

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Bibliographic Details
Main Authors: Balázs Ördög, Alexander Teplenin, Tim De Coster, Cindy I. Bart, Sven O. Dekker, Juan Zhang, Dirk L. Ypey, Antoine A. F. de Vries, Daniël A. Pijnappels
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
optogenetics
in vitro
cellular electrophysiology
action potential
ionic currents
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.710020/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.710020/full

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