Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study

Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study

Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used...

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Bibliographic Details
Main Authors: Zhiliang Wei, Lin Chen, Xirui Hou, Peter C. M. van Zijl, Jiadi Xu, Hanzhang Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neurology
Subjects:
aging
cerebral blood flow
cerebral metabolic rate of oxygen
longitudinal
C57BL/6
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full

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