IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

Abstract Background Inosine 5′-monophosphate dehydrogenase type II (IMPDH2) was originally identified as an oncogene in several human cancers. However, the clinical significance and biological role of IMPDH2 remain poorly understood in colorectal cancer (CRC). Methods Quantitative real-time polymera...

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Bibliographic Details
Main Authors: Shiyu Duan, Wenqing Huang, Xiaoting Liu, Xuming Liu, Nana Chen, Qiong Xu, Yukun Hu, Wen Song, Jun Zhou
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
IMPDH2
Colorectal cancer
Proliferation
Cell cycle
EMT
Online Access:http://link.springer.com/article/10.1186/s13046-018-0980-3

Internet

http://link.springer.com/article/10.1186/s13046-018-0980-3

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