Association between the Hypomethylation of Osteopontin and Integrin β3 Promoters and Vascular Smooth Muscle Cell Phenotype Switching in Great Saphenous Varicose Veins

Association between the Hypomethylation of Osteopontin and Integrin β3 Promoters and Vascular Smooth Muscle Cell Phenotype Switching in Great Saphenous Varicose Veins

Lower extremity varicose veins are a common condition in vascular surgery and proliferation of vascular smooth muscle cells (VSMCs) in the intima is a significant pathological feature of varicosity. However, the pathogenesis of varicose veins is not fully understood. Osteopontin (OPN) could promote...

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Bibliographic Details
Main Authors: Han Jiang, Yu Lun, Xiaoyu Wu, Qian Xia, Xiaoyu Zhang, Shijie Xin, Jian Zhang
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:International Journal of Molecular Sciences
Subjects:
varicosity
vascular smooth muscle cells
phenotype switching
osteopontin
integrin β3
DNA methylation
Online Access:http://www.mdpi.com/1422-0067/15/10/18747

Internet

http://www.mdpi.com/1422-0067/15/10/18747

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