Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.

Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.

Most of colorectal adenocarcinomas are believed to arise from adenomas, which are premalignant lesions. Sequencing the whole exome of the adenoma will help identifying molecular biomarkers that can predict the occurrence of adenocarcinoma more precisely and help understanding the molecular pathways...

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Bibliographic Details
Main Authors: Donger Zhou, Liu Yang, Liangtao Zheng, Weiting Ge, Dan Li, Yong Zhang, Xueda Hu, Zhibo Gao, Jinghong Xu, Yanqin Huang, Hanguang Hu, Hang Zhang, Hao Zhang, Mingming Liu, Huanming Yang, Lei Zheng, Shu Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3534699?pdf=render

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http://europepmc.org/articles/PMC3534699?pdf=render

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