Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers

Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers

Research on mitochondrial metabolism and respiration are rapidly developing areas, however, efficient and widely accepted methods for studying these in solid tumors are still missing. Here, we developed a new method without isotope tracing to quantitate time dependent mitochondrial citrate efflux in...

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Bibliographic Details
Main Authors: Andre Koit, Natalja Timohhina, Laura Truu, Vladimir Chekulayev, Shivakumar Gudlawar, Igor Shevchuk, Katrin Lepik, Lea Mallo, Riina Kutner, Vahur Valvere, Tuuli Kaambre
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
mitochondrial flux
ADP-activated respiration
OXPHOS
citrate
glutaminolysis
metabolic dependencies
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01053/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01053/full

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