Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

Abstract Background Conventional trial design and analysis strategies fail to address the typical challenge of immune-oncology (IO) studies: only a limited percentage of treated patients respond to the experimental treatment. Treating non-responders, we hypothesize, would in part drive non-proportio...

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Bibliographic Details
Main Authors: Zhenzhen Xu, Yongsoek Park, Ke Liu, Bin Zhu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Hematology & Oncology
Subjects:
Cancer immunotherapy
Dichotomized response
Immuno-oncology trial
Non-proportional hazards pattern
Proportional hazards assumption
Sample size and power calculation
Online Access:http://link.springer.com/article/10.1186/s13045-020-0847-x

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http://link.springer.com/article/10.1186/s13045-020-0847-x

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