Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN

Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN

Abstract Background Colorectal cancer (CRC) represents the fourth leading cause of cancer-related deaths. The heterogeneity of CRC identity limits the usage of cell lines to study this type of tumor because of the limited representation of multiple features of the original malignancy. Patient-derive...

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Bibliographic Details
Main Authors: Marta Codrich, Emiliano Dalla, Catia Mio, Giulia Antoniali, Matilde Clarissa Malfatti, Stefania Marzinotto, Mariaelena Pierobon, Elisa Baldelli, Carla Di Loreto, Giuseppe Damante, Giovanni Terrosu, Carlo Ennio Michele Pucillo, Gianluca Tell
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Organoids
Colorectal cancer
Whole exosome sequencing
RNA-seq
PTEN
Online Access:https://doi.org/10.1186/s13046-021-01986-8

Internet

https://doi.org/10.1186/s13046-021-01986-8

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