Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex

Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex

Retinoic acid (RA) plays important roles in development, growth, and homeostasis through regulation of the nuclear receptors for RA (RARs). Herein, we identify Hypermethylated in Cancer 1 (Hic1) as an RA-inducible gene. HIC1 encodes a tumor suppressor, which is often silenced by promoter hypermethyl...

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Bibliographic Details
Main Authors: Haider M. Hassan, Bart Kolendowski, Majdina Isovic, Kerstin Bose, Helen J. Dranse, Arthur V. Sampaio, T. Michael Underhill, Joseph Torchia
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
DNA methylation
active demethylation
retinoic acid
thymine DNA glycosylase
Hypermethylated in Cancer 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306149

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http://www.sciencedirect.com/science/article/pii/S2211124717306149

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