A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

Abstract Background Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential applications in both biomedical research and therapy. Selecting the ops...

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Bibliographic Details
Main Authors: Edward R. Ballister, Jessica Rodgers, Franck Martial, Robert J. Lucas
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Biology
Subjects:
Optogenetics
Opsin
GPCR
GalphaO
Retinal degeneration
Gene therapy
Online Access:http://link.springer.com/article/10.1186/s12915-017-0475-2

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http://link.springer.com/article/10.1186/s12915-017-0475-2

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