Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition

Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition

The prognosis for patients with UM is poor, and recent clinical trials have failed to prolong overall survival (OS) of these patients. Over 95% of UM harbor activating driver mutations, and this allows for the investigation of ctDNA. In this study, we investigated the value of ctDNA for adaptive cli...

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Bibliographic Details
Main Authors: John J. Park, Russell J. Diefenbach, Natalie Byrne, Georgina V. Long, Richard A. Scolyer, Elin S. Gray, Matteo S. Carlino, Helen Rizos
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
uveal melanoma
circulating tumor DNA
next generation sequencing
PKC inhibitor
liquid biopsy
treatment
Online Access:https://www.mdpi.com/2072-6694/13/7/1740

Internet

https://www.mdpi.com/2072-6694/13/7/1740

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